Modelo predictivo de fuerza de agarre para un grupo de trabajadores administrativos de la ciudad de Bogotá / Predictive model of grip strength for a group of administrative workers in Bogota city

Contexto La fuerza de agarre es aquella que se ejerce con la mano para apretar o soltar cualquier objeto, y es considerada un indicador de salud. Autores han concluido que la fuerza de agarre varía dependiendo de la edad, el sexo, la estatura, el peso, hábitos, factores genéticos, entre otros. Objetivos Establecer un modelo matemático para la predicción de la fuerza de agarre de un grupo de trabajadores de oficina de la ciudad de Bogotá. Métodos Con el apoyo de un dinamómetro hidráulico marca Jamar se midió la fuerza de agarre de la mano dominante y no dominante a 293 trabajadores de oficina sanos de una entidad pública de la ciudad de Bogotá. Se siguió el protocolo de la Sociedad Americana de Terapistas de la Mano. La edad, el sexo, la talla, el peso y el IMC fueron registrados para cada participante. Se aplicó la regresión lineal Stepwise para establecer los modelos de predicción para la mano dominante y no dominante, con el software R-Studio. Resultados Los participantes fueron 185 hombres y 108 mujeres, todos con dominancia derecha. En general, los hombres registraron valores más altos de fuerza de agarre respecto a las mujeres. La fuerza de la mano dominante fue superior a la de la mano no dominante. Los modelos matemáticos resultantes permiten estimar la fuerza de agarre de la mano dominante y la mano no dominante con una predictibilidad del 64,52% y el 63,23% respectivamente. Conclusiones Los modelos predictivos propuestos consideraron las variables sexo, talla y peso para la estimación de la fuerza de agarre de la mano dominante, y las variables sexo, talla, peso y edad para la fuerza de agarre de la mano no dominante (AU)

Context Grip strength is the force that is exerted with the hand to squeeze or release any object and it is considered an indicator of health. Authors have concluded that grip strength varies depending on age, sex, height, weight, habits, genetic factors, among others.Objectives To establish a mathematical model for the prediction of grip strength in a group of office workers in the city of Bogotá. Methods The grip strength of the dominant and non-dominant hand was measured with a Jamar hydraulic dynamometer in 293 healthy office workers of a public entity in the city of Bogota. The protocol of the American Society of Hand Therapists was followed. Age, sex, height, weight, and BMI were recorded for each participant. Stepwise linear regression was applied to establish prediction models for the dominant and non-dominant hand, using R-studio software. Results The participants were 185 men and 108 women, all with right dominance. In general, men recorded higher values of grip strength than women. The strength of the dominant hand was higher than that of the non-dominant hand. The proposed mathematical models allow estimating the grip strength of the dominant hand and the non-dominant hand with a predictability of 64.52% and 63.23%, respectively. Conclusions The proposed predictive models included the variables sex, height, and weight for the estimation of the grip strength of the dominant hand, and the variables sex, height, weight and age for the grip strength of the non-dominant hand (AU)

Penfigoide Gestacional / Pemphigoid Gestationis

Resumen 22. Las enfermedades ampollares de tipo penfigoide,se caracterizan por la presencia de ampollas de origen autoinmune.El Penfigoide gestacional(PG), es parte de este grupo de enfermedades y se define por la presencia de una erupción ampollar,intensamente pruriginosa de comienzo agudo, generalmente en el segundo trimestre del embarazo o posparto inmediato, en ocasiones puede haber compromiso fetal y asociarse con otras enfermedades de origen autoinmune.

Abstract 26. Pemphigoid-type bullous diseases are characterized by the presence of blisters of autoimmune origin.Gestational Pemphigoid (PG) is part of this group of diseases and is defined by the presence of an intensely pruritic bullous eruption of acute onset, usually in the second trimester of pregnancy or immediate postpartum period, there may be fetal compromise and associated with other diseases of autoimmune origin.

High-throughput proteomic analysis of candidate biomarker changes in gingival crevicular fluid after treatment of chronic periodontitis.

BACKGROUND AND OBJECTIVE: Untargeted, high-throughput proteomics methodologies have great potential to aid in identifying biomarkers for the diagnosis of periodontal disease. The application of such methods to the discovery of candidate biomarkers for the resolution of periodontal inflammation after periodontal therapy has been investigated. MATERIAL AND METHODS: Gingival crevicular fluid samples were collected from 10 patients diagnosed with chronic periodontitis at baseline and 1, 5, 9 and 13 weeks after completion of mechanical periodontal treatment. Clinical indices of periodontal disease, including probing depth, recession, clinical attachment level and bleeding on probing, were recorded at baseline and 13 weeks. Samples were analyzed using an online liquid chromatography-nanoelectrospray-hybrid ion trap-Orbitrap mass spectrometer. Spectra were processed with the PILOT_PROTEIN proteomics software suite. RESULTS: Clinical parameters were significantly improved 13 weeks after treatment (Wilcoxon signed ranks test, P < .05). From the substantial number of identified proteins, a small subset was extracted by filter methods that included temporal pattern matching, logistic function fitting and mixed-integer linear optimization. This subset includes azurocidin, lysozyme C and myosin-9 as candidate biomarkers prominent at baseline and alpha-smooth muscle actin as prominent 13 weeks after treatment. Cross-validation studies yielded average predictive accuracy and area under the curve of 0.900 and 0.930, respectively. CONCLUSION: High-throughput proteomic analysis can contribute to identifying endpoints of periodontal therapy. These candidate biomarkers should be evaluated for clinical efficacy.

Composición química del aceite esencial de las hojas de Hedyosmum luteynii Todzia (Chloranthaceae)

El objetivo de este trabajo fue la caracterización química del aceite esencial de Hedyosmum luteynii, a partir de muestras recolectadas en el bosque natural Jacarón, cantón Colta, provincia de Chimborazo, Ecuador. El aceite esencial se extrajo por hidrodestilación; el análisis de la composicion se realizó mediante un cromatógrafo de gases acoplado a un espectrómetro de masas; la identificación de los componentes se realizó por comparación de sus espectros de masas y de los índices de Kováts reportados en la literatura. Se identificaron 28 compuestos, correspondientes al 98.62% del total de los constituyentes, siendo la mayoría monoterpenos hidrocarburos naturales (83.21%). Los constituyentes más abundantes fueron: α-felandreno (32.72%), α-pineno (13.20%), (Z)-β-ocimeno (10.99%), silvestreno (6.51%), biciclogermacreno (5.05%), 1.8-cineol (4.95%), (E)-β-ocimeno (3.88%) y germacreno D (3.20%). Es la primera vez que se reporta al silvestreno como un componente importante en el aceite esencial de una de las especies del genero Hedyosmum. Este resultado hace evidente una marcada diferencia en la composición química del aceite esencial de H. luteynii respecto a otras especies del género Hedyosmum.

In this work, essential oil of Hedyosmum luteynii is characterize from samples collected in the Jacarón natural forest, Colta, Chimborazo, Ecuador. The essential oil was extracted by hydrodistillation; analysis of the composition was carried out by gas chromatograph, coupled to a mass spectrometer; identification of the components was made by comparing their mass spectra and the Kováts indexes reported in the literature. Twenty-eight compounds were identified, 98.62% of the total components. Natural hydrocarbon monoterpenes were the highger (83.21%). The most abundant components were: α-phellandrene (32.72%), α-pinene (13.20%), (Z)-β-ocimene (10.99%), silvestrene (6.51%), bicyclogermacrene (5.05%), 1.8-cineol (4.95%), (E)-β-ocimene (3.88%) and germacrene D (3.20%). For first time, silvestrene is reported as an important component of essential oil in one of the species of the genus Hedyosmum. This result is a important difference in the chemical composition of the essential oil of H. luteynii respect to other species of Hedyosmum.

Mitochondrial DNA suggests cryptic speciation in Prodiplosis longifila Gagné (Diptera: Cecidomyiidae) associated with geographic distance and host specialization.

Prodiplosis longifila is reported as a pest of a wide range of species cultivated in America, including citrus, solanaceous species and asparagus. This species has different behavioural traits that are primarily centred on the oviposition habit and the feeding of larvae, which can change depending on the host. However, scarce information is available on population studies and the natural history of this insect, and uncertainty exists about the taxonomic identity and the geographic distribution of this species. The main objective was to perform a phylogenetic and genetic study of P. longifila populations and to define whether the North American and South American populations belong to the same species or whether a differentiation process had occurred due to geographic distance. A second objective was to determine whether this species showed genetic differentiation by host specialization in South America. The phylogenetic and population analyses based on DNA barcodes (cytochrome oxidase I gene) and a region of the ribosomal DNA (ITS2) revealed divergent clades attributable to geographic distance and host specificity. The North American and South American P. longifila insects were confirmed to be genetically distinct, and the genetic distances exceeded the values expected for intraspecific variation. In South America, the population analysis of P. longifila from tomato, sweet pepper (Solanaceae), Tahiti lime and key lime (Rutaceae) hosts evidenced high genetic differentiation between populations associated with different hosts and an absence of gene flow between these groups, suggesting the corresponding formation of cryptic species.

[Benefits of the 2002-2003 National Program of Extramural Surgery of the ministry of health in ophthalmologic care]. / Logros 2002-2003 del Programa Nacional de Cirugía Extramuros en la atención oftalmológica.

In a recent past article, we reported the general considerations of the national program of extramural surgery in Mexico from the national health secretary. The results obtained concerning ophthalmic care during the last 2 years are presented to provide new information about what has been done in our country, in specialized ophthalmologic care to the economically disadvantaged population who do not have access to other types of medical ophthalmic attention, especially for cataracts and strabismus.

[Chronic constipation. Use of cisapride]. / Estreñimiento crónico. Uso del cisapride.

We studied the effect of Cisapride (10 mg vo every 8 hours) on the characteristics of the evacuations, orocoecal transit time and motility trough rectoanal manometry in patients diagnosed with chronic constipation. The patients (N = 51) received placebo and/or drug in a controlled, randomized, double blind, crossed study during two treatment phases of 30 days each. The end of each phase was followed by a clinical evaluation, a rectoanal manometry and hydrogen breath test. Cisapride increased the rhythm of ecacuations (5.53 days +/- 3.11 vs 1.59 days +/- 1.15 p < 0.05) improved the frequency of evacuations and diminished the consistency of the feces (p < 0.05), shortened the orocoecal transit time (271.57 min +/- 9.87 vs 201.18 min +/- 29.30 p < 0.05) and improved the parameters of the rectoanal manometry readings such as the pressure of internal anal sphincter (58.14 mmHg 7.33 vs 53.90 mmHg 5.19 p < 0.05), and its relaxation percentage (73.41% +/- 15.30 vs 66.84% +/- 11.83 p < 0.05). Side effects associated with Cisapride were not significant. It is concluded that Cisapride improves intestinal motility in chronic constipation.

Elevated surfactant protein A in bronchoalveolar lavage fluids from sarcoidosis and hypersensitivity pneumonitis patients.

Interstitial lung diseases often are accompanied by histopathologic evidence of alveolar type 2 cell alterations. In the alveolar milieu, the surfactant-specific protein A (SP-A) is a secretory product of alveolar type 2 cells. Therefore, we measured SP-A levels in bronchoalveolar lavage (BAL) fluids from patients with untreated sarcoidosis (n = 35) and hypersensitivity pneumonitis (HP [n = 10]) and compared the results with those from 21 healthy control subjects. In sarcoidosis patients, SP-A was markedly higher than in control subjects with a mean of 8.0 micrograms/ml of recovered BAL fluid +/- 0.7 SEM (p < 0.0001 compared with control subjects). In HP, SP-A values were comparable with those in sarcoidosis with a mean of 9.0 micrograms/ml +/- 1.7 SEM. Mean SP-A in the control group was 4.0 micrograms/ml +/- 0.3 SEM. These results suggest that SP-A secretion is stimulated in sarcoidosis and HP. Further studies seem justified to investigate the role of the surfactant system in interstitial lung diseases as well as the potential clinical usefulness of SP-A measurements in BAL.

Vagotomía por laparoscopia: primera experiencia en Colombia / Laparoscopy vagotomy: first experience in Colombia

Se presentan 2 casos de enfermedad ulcerosa tratados con vagotomia troncular posterior y supraselectiva anterior por laparoscopia, realizados en la Fundacion Santa Fe de Bogota, siendo esta la primera experiencia en Colombia. Se describe la tecnica quirurgica y se revisan las alternativas existentes para el tratamiento actual de la ulcera peptica por laparoscopia. La tecnica descrita de vagotomia troncular posterior y supraselectiva anterior es probablemente la que se va a imponer como procedimiento laparoscopico de eleccion, por cuanto ofrece una buena y nueva alternativa para el tratamiento definitivo de la ulcera peptica. Es necesario observar el seguimienio de un mayor número de pacientes por un lapso prolongado, para evaluar la incidencia de recurrencia con este nuevo procedimiento basado en principios quirurgicos y fisiopalologicos ya establecidos.